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Pre-Conference Workshops
Monday 18th November 2019

Registration and Welcome Coffee
8:30 – 9:00

WORKSHOP A

Biomarkers 101
9:00 – 12:00

Session Purpose:

  • Novel biomarkers: how to create them and how to apply them
  • Hands-on demonstration of biomarker application to preclinical and clinical models
  • Medical imaging and blood tests: the pros and cons of the latest technology
  • Translating in vivo and in vitro models to clinical trials through consistent biomarker application

Workshop Leader

Sydney Montesi

Sydney Montesi M.D.
Assistant Professor of Medicine
Harvard University

Lunch Networking Break
12:00 – 13:00

WORKSHOP B

How to cure multifactorial fibrotic diseases “Kill Two Birds With One Stone: MRI-1867, Hybrid Inhibitor of Peripheral Cannabinoid Receptor 1 (CB1R) & Inducible Nitric Oxide Synthase (iNOS), for the Treatments of NASH & Liver, Lung and Skin fibrosis”
13:00 – 16:00

Session Purpose:

  • Outlining rationale for multi-target approach by polypharmacology to develop effective therapies in complex progressive diseases such as NASH and fibrotic diseases
  • Identifying dual targeting of peripheral cannabinoid receptor 1 (CB1R) and inducible nitric oxide synthase (iNOS) as an effective therapeutic strategy in obesity, diabetes, AFLD, NAFLD, NASH, liver, lung and skin fibrosis
  • Introducing the concept of third-generation cannabinoid receptor 1 (CB1R) antagonists for metabolic and fibrotic disorders
  • Demonstrating preclinical efficacy of MRI-1867, an orally bioavailable small molecule antagonist of peripheral CB1R/iNOS, in fibrotic disorders: liver, lung and skin fibrosis

Workshop Leader

Resat Cinar

Resat Cinar
Staff Scientist
National Institute on Alcohol Abuse & Alcoholism

WORKSHOP C

Mechanistic workshop: Inhibitors
13:00 – 16:00

Session Purpose:

  • Discover fibrotic inducers to create the perfect mechanistic antidote
  • Decipher the biological elements lacking in a fibrotic patient but found in a healthy patient
  • The creation of inhibiting treatments: from R&D to clinical trials

Workshop Leaders

Richard Stratton

Dr Richard Stratton
Consultant Physician and Honorary Senior Lecturer
University College London

Rana Herro

Rana Herro
Junior Faculty Lecturer
La Jolla Institute of Immunology

Networking Coffee to Stay or Go
16:00 – 16:30