The Conference will return in November 2021, Register Your Interest Here
7:30 am Conference Registration & Networking
7:55 am Chair’s Opening Remarks
Enhancing Understanding of Fibrotic Disease Cell Types & Pathogenesis to Inform the Next Generation of Druggable Targets
8:00 am Single Cell RNA Sequencing
8:30 am The Impact of Nintedanib on the Single Cell Seq Profile of Macrophage Populations in the Lungs of Mice
9:00 am Targeting Senescent Cells: Friend or Foe?
9:30 am The Intricate Role of the Collagen Machinery in Fibrosis for Biomarker Use
Synopsis
- The good and the bad collagens of fibrosis – and their role in organ function and extracellular matrix integrity
- Identification of early efficacy and fibrosis progressors and regressors in fibrotic diseases based on the serological collagen profile
9:45 am
Speed Networking
Synopsis
This session is the ideal opportunity to get face-to-face time with many of the brightest minds working in the AFDD field and establish meaningful business relationships to pursue for the rest of the conference, all from the comfort of your own home or office.
10:30 am Morning Break & Networking
Identifying, Validating & Targeting: What are the Pathological Relationships & How do we Target Them?
11:00 am Interrogating & Visualizing Fibrosis to Identify Therapeutic Opportunities for Treating Age Related Macular Degeneration
11:30 am Targeting Metabolic Remodeling in Fibrosis
12:00 pm Targeting Fibrosis in the Liver With Pro-Apoptotic Drugs
12:30 pm Novel Cannabinoid Receptor 2 Selective Agonist for The Treatment of Fibrosis
1:00 pm
Lunch & Networking
2:00 pm Antibody-mediated Inhibition of CD38 for the Treatment of Inflammation and Fibrosis
2:30 pm Mechano-therapeutics: Targeting Mechanical Signalling in Fibrosis
3:00 pm Quickfire on the Key Topics – Imaging, Modeling & Artificial Intelligence
Synopsis
This is your opportunity to engage in an interactive presentation and discussion on the hottest topics in the antifibrotic drug development space.
Join one of the sessions below to discover more about each speakers expertise through a short presentation and Q&A session with your peers.
| Discovering the Role of Imaging in Quantification of Fibrotic Lung Disease & Implications for Other Fibrotic Diseases |
Deep Dive Into the Role of Machine Learning in Antifibrotic Therapy
|
Harnessing the Power of Emerging in Vitro Technologies
|
||
| • Understanding common imaging findings for fibrotic diseases and their implications • Exploring new imaging strategies for fibrosis analysis • Outlining the value of quantifying fibrosis |
• Exploring the potential for AI in anti-fibrotic therapeutics: can we use algorithms for improving the anti-fibrotic response? • Uncovering the benefits & drawbacks of patient-tailoring of anti fibrotics • Determining the parameters to be used in fibrosis algorithms: focus on host-related, disease related & environment-related |
• Reflecting on the progress in precision cut slice technology over the past year • Reviewing how to replicate organ culture • Outlining how to ensure a smoother transition into clinical trials |
||
| Mary Salvatore, Professor, University of Columbia Sachin Jambawalikar |
Illan Yaron, Director, Department of Medicine at Hadassah, Hebrew University |
Lee Borthwick, Senior Lecturer in Fibrosis Biology, Newcastle University |