Decoding the Fibrotic Circuitry to Sharpen Discovery with Mechanistic Clarity & Context-Specific Targeting
Time: 11:00 am - 1:00 pm
day: Pre-Conference Day
Details:
As antifibrotic drug development evolves, a deeper understanding of the cellular
architecture and communication networks that drive fibrosis is critical. This workshop explores fibroblast biology across indications, highlighting how tissue-specific and conserved mechanisms can better inform early target selection and derisk downstream development.
This workshop will gather experts to discuss:
- Dissecting immune–fibroblast, epithelial–fibroblast, and vascular–fibroblast interactions to uncover common vs divergent signaling mechanisms
- Evaluating the therapeutic implications of context-specific TGF-β inhibition (selective targeting of ECM-bound pro-TGFβ1) and navigating the balance between efficacy and toxicity
- How spatial omics, niche-specific activation cues, and cross-organ learnings are enabling more precise, safer antifibrotic strategies.
