From Epithelial Repair to Durable Benefit: AT2 Receptor Agonism as an Upstream Intervention in Fibrotic Disease
12:00 pm - Wednesday 2nd December 2026
- AT2 receptor agonism restores the protective arm of the renin–angiotensin system, promoting epithelial resilience and repair following alveolar injury – an early pathogenic event that can contribute to inflammation, metabolic dysfunction, vascular remodelling, and fibrosis
- Positioning the AT2 receptor as an upstream modulatory node at the intersection of fibrotic remodelling: where diverse pathological insults converge on shared profibrotic pathways, while disease-specific biology defines therapeutic opportunity and indication boundaries
- Translational evidence for AT2 receptor agonism in fibrotic disease in preclinical and early clinical studies
