Roundtable: Exploring Cancer Associated Fibroblasts, Macrophages & Apoptotic Machinery for Targeting Fibrosis

Time: 2:00 pm
day: Day 2 - Stream A


• Translating learnings from cancer associated fibroblasts (CAF) in the tumor microenvironment to manipulating CAR-T cells to treat fibrosis
• Reviewing macrophage subsets, their cellular interactions in the matrix & role in fibrosis pathogenesis
• Exploring the resistance to apoptosis through the expansion of fibroblasts in promoting fibrotic injury

Roundtable: Tailoring Clinical Trials to Improve Likelihood of Meeting Trial Endpoints & More Quickly Determining Drug Success
• Validating new clinical trial endpoints to test antifibrotic agents
• Leveraging biomarker testing to inform clinical trial design
• Embedding patient stratification into clinical trials to demonstrate drug effect and improve drug outcomes