Targeting Mechanobiology to Disrupt Self-Sustaining Fibrosis: A New Path to Disease Reversal
4:45 pm - Wednesday 2nd December 2026
- Understanding how matrix stiffness and mechanical signaling create self-sustaining fibrotic pathways across organs, independent of the initiating injury or inflammation
- Identifying and validating druggable nodes across the mechanotransduction pathway, from focal-adhesion mechanosensors to downstream transcriptional effectors
- Applying emerging discovery platforms and translational models to develop selective mechanobiology-targeted therapies that disrupt fibrotic tissue while preserving normal homeostasis and repair
